Bielschowskysin, a Gorgonian-Derived Biologically Active Diterpene with an Unprecedented Carbon Skeleton
Organic Letters2004Vol. 6(10), pp. 1661–1664
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Jeffrey Marrero, Abimael D. Rodrı́guez, P. Baran, Raphael G. Raptis, Juan A. Sánchez, Eduardo Ortega‐Barría, Todd L. Capson
Abstract
Bielschowskysin is a naturally occurring diterpene isolated from the Caribbean gorgonian octocoral Pseudopterogorgia kallos. Its highly oxygenated hexacyclic structure is based on a previously undescribed tricyclo[9.3.0.0(2,10)]tetradecane ring system that was established through spectroscopic analysis and X-ray crystallographic analysis. Bielschowskysin was shown to exhibit antimalarial activity against Plasmodium falciparum as well as strong anticancer activity against two human cancer cell lines.
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