Selective Functionalization in Positions 2 and 3 of Indole via an Iodine−Copper Exchange Reaction
Organic Letters2004Vol. 6(10), pp. 1665–1667
Citations Over TimeTop 10% of 2004 papers
Abstract
Two selectively successive I/Cu exchange reactions performed with (Nphyl)CuLi allow the functionalization of indoles in positions 2 and 3. The 2,3-diketones prepared by this method can readily be converted to tricyclic heterocycles by standard methods.
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