Investigation of the Rh-Catalyzed Asymmetric Reductive Aldol Reaction. Expanded Scope Based on Reaction Analysis
Organic Letters2004Vol. 6(14), pp. 2309–2312
Citations Over TimeTop 10% of 2004 papers
Abstract
[reaction: see text] A series of experiments are described that suggest that the Rh-catalyzed reductive aldol reaction proceeds by addition of a Rh(I) hydride, generated in situ, to the reacting acrylate followed by a stereochemistry-controlling aldol addition reaction. On the basis of this hypothesis, reaction conditions are engineered that allow for increased substrate scope.
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