Diastereoselective Aldol Reaction of N,N-Dibenzyl-α-amino Aldehydes with Ketones Catalyzed by Proline
Organic Letters2004Vol. 6(6), pp. 1009–1012
Citations Over TimeTop 10% of 2004 papers
Abstract
[reaction: see text] L-proline-catalyzed direct aldol reaction of L-amino acid-derived N,N-dibenzyl amino aldehydes with acetone, cyclopentanone, or hydroxyacetone provides gamma-amino-beta-hydroxy- or gamma-amino-alpha,beta-dihydroxy-ketones with moderate to excellent yields and diastereoselectivities.
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