A Highly Efficient Procedure for 3-Sulfenylation of Indole-2-carboxylates
Organic Letters2004Vol. 6(5), pp. 819–821
Citations Over TimeTop 10% of 2004 papers
Abstract
A highly efficient one-pot procedure for 3-sulfenylation of 2-carboxyindoles is described. Treatment of thiols with N-chlorosuccinimide at -78 degrees C in CH(2)Cl(2) affords sulfenyl chlorides in situ that readily react with 2-carboxyindoles to give 3-thioindoles in high yields. This new method is milder, produces less waste, and is compatible with a wide range of thiol and indole functionality. [reaction: see text]
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