aza-Prins-pinacol Approach to 7-Azabicyclo[2.2.1]heptanes and Ring Expansion to [3.2.1]Tropanes
Organic Letters2005Vol. 7(7), pp. 1335–1338
Citations Over TimeTop 16% of 2005 papers
Abstract
[reaction: see text] The 7-azabicyclo[2.2.1]heptane ring system can be rapidly accessed from 5-(1-hydroxyallyl)-2-alkoxy-N-tosylpyrrolidines via an unusual aza-Prins-pinacol reaction mediated by Lewis acid. The products can undergo ring expansion to isomeric tropanones. These reactions show promise for a concise entry to biologically relevant azabicyclic targets.
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