Diversifying Vancomycin via Chemoenzymatic Strategies
Organic Letters2005Vol. 7(8), pp. 1513–1515
Citations Over TimeTop 10% of 2005 papers
Abstract
[reaction: see text] The rapid diversification of glycopeptides via glycorandomization reveals that significantly diverse substitutions are tolerated and suggests there may be a synergistic benefit to the construction of mechanistically related natural product core scaffold fusions. This work also further highlights the utility of chemoenzymatic approaches to diversify complex natural product architectures.
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