From Azides to Nitriles. A Novel Fast Transformation Made Possible by BrF3
Organic Letters2005Vol. 7(11), pp. 2177–2179
Citations Over TimeTop 17% of 2005 papers
Abstract
Various alkyl and aryl azides, readily obtained from halides or alcohols, were transformed into the corresponding nitriles using bromine trifluoride in moderate to good yields. The reaction is general and gives positive results with aliphatic, aromatic, cyclic, and functionalized azides. It can also be applied to the synthesis of optically active nitriles.
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