Efficient Synthesis of α-Galactosyl Ceramide Analogues Using Glycosyl Iodide Donors
Organic Letters2005Vol. 7(10), pp. 2063–2065
Citations Over TimeTop 10% of 2005 papers
Abstract
The combination of reactive galactosyl iodide donors with electron-rich acceptor lipids provides highly stereoselective and efficient routes to alpha GalCer analogues. Using per-O-silylated donors, key intermediates can be obtained in a three-step, one-pot sequence providing useful constructs for analogue development.
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