Stereocontrolled Assembly of Tetrasubstituted Tetrahydrofurans: A Concise Synthesis of Virgatusin
Organic Letters2005Vol. 7(17), pp. 3685–3688
Citations Over TimeTop 11% of 2005 papers
Abstract
The condensation of substituted allylsiloxanes with aldehydes leads to the highly stereoselective construction of 2,3,4,5-tetrasubstituted tetrahydrofurans. With electron-rich aryl and alpha,beta-unsaturated aldehydes as substrates, the stereochemical outcome at C5 can be dictated by appropriate choice of Lewis acid. The reaction has been applied to a concise (nine step) synthesis of (+)-virgatusin (ent-1). [reaction: see text]
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