N-Trifluoroacetyl Sialyl Phosphite Donors for the Synthesis of α(2 → 9) Oligosialic Acids
Organic Letters2005Vol. 7(19), pp. 4169–4172
Citations Over TimeTop 12% of 2005 papers
Abstract
[reaction: see text] A new method for the synthesis of alpha(2 --> 9) oligosialic acids is developed using phosphite sialyl donors that are protected with a C-5 N-trifluoroacetyl (NHTFA) substituent. Compared with conventional donors, these donors gave a higher degree of alpha-anomeric selectivity during glycosidic bond formation and better yields during iterative sialylation in the synthesis of oligosialic acids.
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