Pyrazolo[1,5-a]pyridines as p38 Kinase Inhibitors
Organic Letters2005Vol. 7(21), pp. 4753–4756
Citations Over TimeTop 25% of 2005 papers
Kirk L. Stevens, David Jung, Michael J. Alberti, Jennifer G. Badiang, Gregory E. Peckham, Jim M. Veal, Mui Cheung, Philip A. Harris, Stanley D. Chamberlain, Michael Peel
Abstract
[reaction: see text] A convergent synthesis of substituted pyrazolo[1,5-a]pyridines has been achieved either via a regioselective [3 + 2] cycloaddition of N-aminopyridines with alkynes or by thermal cyclization of disubstituted azirines. Subsequent palladium-catalyzed introduction of pyridines or de novo synthesis of pyrimidines affords inhibitors of p38 kinase.
Related Papers
- A GEOMETRIC MEAN IN THE FURUTA INEQUALITY(2002)
- Susquehanna Chorale Spring Concert "Roots and Wings"(2017)
- Коммуникaтивно- прaгмaтический aнaлиз дипломaтических бумaг (нa основе вербaльных нот)(2018)
- → ФОРМИРОВAНИЕ ГОТОВНОСТИ БУДУЩИХ ПЕДAГОГОВ К ОРГAНИЗAЦИИ РAБОТЫ ПО РAЗВИТИЮ ВAЛЕОЛОГИЧЕСКОЙ КУЛЬТУРЫ ШКОЛЬНИКОВ(2023)