Pd-Catalyzed Silicon Hydride Reductions of Aromatic and Aliphatic Nitro Groups
Organic Letters2005Vol. 7(22), pp. 5087–5090
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Abstract
[reaction: see text] Room-temperature reduction of aromatic nitro groups to amines can be accomplished in high yield, with wide functional group tolerance and short reaction times (30 min) using a combination of palladium(II) acetate, aqueous potassium fluoride, and polymethylhydrosiloxane (PMHS). Replacing PMHS/KF with triethylsilane allows aliphatic nitro groups to be reduced to their hydroxylamines.
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