Asymmetric Direct Vinylogous Michael Reaction of Activated Alkenes to Nitroolefins Catalyzed by Modified Cinchona Alkaloids
Organic Letters2005Vol. 7(23), pp. 5293–5296
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Abstract
[reaction: see text] The first organocatalytic and asymmetric direct vinylogous Michael reaction that employs the electron-deficient vinyl malononitriles as the nucleophilic species has been reported. The novel transformations exhibit exclusive gamma-selectivity and high diastereo- and enantioselectivity in the addition to nitroolefins, which give the multifunctional products with two vicinal chiral centers.
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