Liphagal, a Selective Inhibitor of PI3 Kinase α Isolated from the Sponge Aka coralliphaga: Structure Elucidation and Biomimetic Synthesis
Organic Letters2005Vol. 8(2), pp. 321–324
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Frédéric Marion, David E. Williams, Brian O. Patrick, Irwin Hollander, Robert Mallon, Steven C. Kim, Deborah M. Roll, Larry Feldberg, Rob W. M. van Soest, Raymond J. Andersen
Abstract
[structure: see text] Liphagal (1), a selective inhibitor of PI3K alpha, has been isolated from the marine sponge Aka coralliphaga collected in Dominica. The "liphagane" meroterpenoid carbon skeleton of liphagal (1) is new. A biomimetic total synthesis has been used to confirm the constitution of liphagal (1) and support a proposed biogenesis.
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