Potent Algicides Based on the Cyanobacterial Alkaloid Nostocarboline
Organic Letters2006Vol. 8(4), pp. 737–740
Citations Over TimeTop 10% of 2006 papers
Judith F. Blom, Tobias Michael Brütsch, Damien Barbaras, Yann Bethuel, Hans H. Locher, Christian Hubschwerlen, Karl Gademann
Abstract
[structure: see text] Nostocarboline and seven derivatives were prepared and displayed minimal inhibitory concentration (MIC) values >or=100 nM against the growth of Microcystis aeruginosa PCC 7806, Synechococcus PCC 6911, and Kirchneriella contorta SAG 11.81, probably via the inhibition of photosynthesis. The natural product hybrid nostocarboline/ciprofloxacin displayed additional antibacterial activity against several Gram-negative bacteria (MICs >or=0.7 microM). Nostocarboline can thus be considered a potent, selective, readily available, natural algicide.
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