Stereocontrolled Formation of Amino Acids and N-Heterocycles Bearing a Quaternary Chiral Carbon
Organic Letters2006Vol. 8(5), pp. 939–942
Citations Over TimeTop 14% of 2006 papers
Abstract
Stereocontrolled formation of tertiary or quaternary chiral carbons bearing nitrogen was achieved using the [3,3]-sigmatropic rearrangement of cyanate to isocyanate as a key element. A short and highly selective sequence of reactions, starting from p-menthane-3-carboxaldehyde, was developed leading to alpha,alpha-dialkylated alpha-amino acids or N-heterocycles, depending on the method of cleavage of the auxiliary.
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