Enantioselective Synthesis of a PKC Inhibitor via Catalytic C−H Bond Activation
Organic Letters2006Vol. 8(8), pp. 1745–1747
Citations Over TimeTop 10% of 2006 papers
Abstract
[reaction: see text] The syntheses of two biologically active molecules possessing dihydropyrroloindole cores (1 and 2) were completed using rhodium-catalyzed imine-directed C-H bond functionalization, with the second of these molecules containing a stereocenter that can be set with 90% ee during cyclization using chiral nonracemic phosphoramidite ligands. Catalytic decarbonylation and direct indole/maleimide coupling provide efficient access to 2.
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