Highly Efficient and Reusable Dendritic Catalysts Derived fromN-Prolylsulfonamide for the Asymmetric Direct Aldol Reaction in Water
Organic Letters2006Vol. 8(20), pp. 4417–4420
Citations Over TimeTop 1% of 2006 papers
Abstract
The direct aldol reactions catalyzed by chiral dendritic catalysts derived from N-prolylsulfonamide gave the corresponding products in high isolated yields (up to 99%) with excellent anti diastereoselectivities (up to >99:1) and enantioselectivities (up to >99% ee) in water. In addition, catalyst 1e may be recovered by precipitation and filtration and reused for at least five times without loss of catalytic activity.
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