Synthesis of 3-(Aryl)alkenyl-β-lactams by an Efficient Application of Olefin Cross-Metathesis on Solid Support
Organic Letters2006Vol. 8(21), pp. 4783–4786
Citations Over TimeTop 11% of 2006 papers
Abstract
[reaction: see text] An efficient cross-metathesis on solid support for the synthesis of beta-lactam analogues of cholesterol absorption inhibitors is described. The applied strategy allows the introduction of diversity in positions 3 and 4 of the beta-lactam ring with excellent 3,4-trans selectivity and complete E selectivity at the C-3 side chain.
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