Substrate-Directed Stereoselectivity in Vicinal Diamine-Catalyzed Synthesis of Warfarin
Organic Letters2006Vol. 8(23), pp. 5239–5242
Citations Over TimeTop 10% of 2006 papers
Abstract
[Structure: see text] A new mechanism involving a diimine intermediate is proposed for vicinal diamine-catalyzed synthesis of warfarin. Decreasing the NCCN dihedral angle by varying the diamine results in an increase in the enantioselectivity of warfarin synthesis.
Related Papers
- → Chemistry of organoditins. I. Stereochemistry of dehalogenation of vicinal dihalides.(1973)3 cited
- → ChemInform Abstract: Diastereoselective Synthesis of Vicinal Amino Alcohols(2012)
- → ChemInform Abstract: A New, Selective Method for Conversion of Alcohols to Vicinal Fluorohydrins.(1994)
- → ChemInform Abstract: DDQ‐Mediated Oxidation of sp3 C—H Bond for the Direct Synthesis of Vicinal Tricarbonyl Compounds.(2014)
- → ChemInform Abstract: Convergent, Asymmetric Synthesis of Vicinal Amino Alcohols via Rh‐Catalyzed Addition of α‐Amido Trifluoroborates to Carbonyls.(2014)