Synthesis of β,γ-Unsaturated Lactams via a Magnesium Iodide Promoted Ring Expansion of Secondary Methylenecyclopropyl Amides
Organic Letters2006Vol. 8(24), pp. 5521–5524
Citations Over TimeTop 17% of 2006 papers
Abstract
A novel and efficient route to exo-beta,gamma-unsaturated lactams from substituted and non-substituted secondary methylenecyclopropyl amides is reported. Subsequent modification of the resulting exo-beta,gamma-unsaturated lactams provides access to several pharmaceutically relevant scaffolds. [reaction: see text].
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