Chlorahololides A and B, Two Potent and Selective Blockers of the Potassium Channel Isolated fromChloranthus holostegius
Organic Letters2007Vol. 9(5), pp. 903–906
Citations Over TimeTop 10% of 2007 papers
Sheng‐Ping Yang, Zhaobing Gao, Fang‐Dao Wang, Shang‐Gao Liao, Huadong Chen, Chuan‐Rui Zhang, Guo‐Yuan Hu, Jian‐Min Yue
Abstract
[structure: see text] Chlorahololides A(1) and B(2), two highly complex sesquiterpenoid dimers, were isolated from Chloranthus holostegius. Their structures and absolute configurations were established by NMR spectroscopy, X-ray crystallography, and CD. Chlorahololides A (1) and B (2) exhibited potent and selective inhibition on the delayed rectifier (IK) K+ current, with an IC50 of 10.9 and 18.6 microM, respectively.
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