New Electrophilic Difluoromethylating Reagent
Organic Letters2007Vol. 9(10), pp. 1863–1866
Citations Over TimeTop 10% of 2007 papers
Abstract
A new electrophilic difluoromethylating reagent has been developed. The S-(difluoromethyl)diarylsulfonium tetrafluoroborate has been shown to be effective for the introduction of an electrophilic difluoromethyl group into the following nucleophiles: sulfonic acids, tertiary amines, imidazole derivatives, and phosphines. The reagent failed to transfer the difluoromethyl group to phenols, carbon nucleophiles, and primary and secondary amines.
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