Origins of the High 14-Helix Propensity of Cyclohexyl-Rigidified Residues in β-Peptides
Organic Letters2007Vol. 9(9), pp. 1801–1804
Citations Over TimeTop 12% of 2007 papers
Myung‐Ryul Lee, Tami L. Raguse, Marina Schinnerl, William C. K. Pomerantz, Xiaodong Wang, Peter Wipf, Samuel H. Gellman
Abstract
[structure: see text] beta-Peptides containing residues derived from trans-2-aminocyclohexanecarboxylic acid (ACHC) display high population of 14-helical secondary structure in aqueous solution. We show that hydrophobic interactions between cyclohexyl rings are not responsible for this conformation-promoting effect, and that polar groups may be attached to the cyclohexyl ring without diminishing the effect.
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