Highly Enantioselective Synthesis of γ-Hydroxy-α,β-acetylenic Esters Catalyzed by a β-Sulfonamide Alcohol
Organic Letters2007Vol. 9(12), pp. 2329–2332
Citations Over TimeTop 10% of 2007 papers
Abstract
This work concerns the asymmetric addition of methyl propiolate to aldehydes with 1,2-dimethoxyethane (DME) as additive and beta-sulfonamide alcohol titanium complex as a catalyst. The reactions proceeded under mild conditions and gave the highly functionalized chiral propargylic alcohols with high ee values and good yields. Differences between three types of ligands have also been discussed.
Related Papers
- → Recent developments in enantioselective iron-catalyzed transformations(2019)58 cited
- → Alternative Synthetic Strategies for Enantioselective Construction of Halogenated Chiral Carbon Centers(2010)37 cited
- → Methods of Asymmetric Synthesis—Enantioselective Catalytic Hydrogenation(1971)142 cited
- → Conductivities of 1,2-dimethoxyethane or 1,2-dimethoxyethane-related solutions of lithium salts(1993)13 cited
- → Chiral B(III) Lewis Acids(2000)19 cited