One-Step Synthesis of Heteroaromatic-Fused Pyrrolidines via Cyclopropane Ring-Opening Reaction: Application to the PKCβ Inhibitor JTT-010
Organic Letters2007Vol. 9(17), pp. 3331–3334
Citations Over TimeTop 10% of 2007 papers
Masahiro Tanaka, Minoru Ubukata, Takafumi Matsuo, Katsutaka Yasue, Katsuya Matsumoto, Yasuyuki Kajimoto, Takashi Ogo, Takashi Inaba
Abstract
A ring-opening reaction of cyclopropanes with five-membered heteroaromatics having a leaving group at C(2) was found to provide heteroaromatic-fused pyrrolidines in one step. This reaction was successfully applied to the synthesis of the protein kinase C-beta inhibitor JTT-010, which possesses a dihydropyrrolo[1,2-a]indole core.
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