Passerini Three-Component Reaction of Alcohols under Catalytic Aerobic Oxidative Conditions
Organic Letters2010Vol. 12(7), pp. 1432–1435
Citations Over TimeTop 10% of 2010 papers
Abstract
Alcohols instead of aldehydes were used in the Passerini three-component reaction under catalytic aerobic conditions. Mixing alcohols, isocyanides, and carboxylic acids in toluene in the presence of a catalytic amount of cupric chloride, NaNO(2), and TEMPO afforded, under an oxygen atmosphere, the P-3CR adducts in good yields.
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