Mild and General Method for the α-Arylation of Heteroaromatic Ketones
Organic Letters2010Vol. 12(5), pp. 1032–1035
Citations Over TimeTop 10% of 2010 papers
Abstract
The development of a general and mild method for Pd-catalyzed alpha-arylation of a variety of ketones bearing multiple heteroatoms is described. The ligand to metal ratio and the position of the heteroatoms with respect to the carbonyl moiety significantly impact the efficiency of these transformations. In addition, these conditions were successfully applied to the alpha-arylation of cyclic imines. A detailed investigation of the scope of this methodology, including the effect of the ligand to metal ratio, is discussed.
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