Transition-Metal-Free Electrophilic Amination between Aryl Grignard Reagents andN-Chloroamines
Organic Letters2010Vol. 12(7), pp. 1516–1519
Citations Over TimeTop 10% of 2010 papers
Abstract
In the presence of N,N,N',N'-tetramethylethylenediamine (TMEDA) as an additive, easily prepared and handled N-chloroamines react with aryl Grignard reagents to give a variety of arylamines in good to excellent yields. Functional groups such as ester and nitrile are compatible under the reaction conditions.
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