Azonazine, a Novel Dipeptide from a Hawaiian Marine Sediment-Derived Fungus, Aspergillus insulicola
Organic Letters2010Vol. 12(20), pp. 4458–4461
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Quan-Xiang Wu, Mitchell S. Crews, Marija Drašković, Johann Sohn, Tyler A. Johnson, Karen Tenney, Frederick A. Valeriote, Xiao-Jun Yao, Leonard F. Bjeldanes, Phillip Crews
Abstract
Azonazine, a unique hexacyclic dipeptide, was isolated from a Hawaiian marine sediment-derived fungus eventually identified as Aspergillus insulicola. Its absolute configuration, 2R,10R,11S,19R, was established using NMR, HRESIMS, and CD data plus insights derived from molecular models. A possible route for its biogenesis is proposed, and biological properties were explored against cancer cell lines and in an NFκB inhibition assay.
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