Verticilactam, a New Macrolactam Isolated from a Microbial Metabolite Fraction Library
Organic Letters2010Vol. 12(20), pp. 4564–4567
Citations Over TimeTop 13% of 2010 papers
Toshihiko Nogawa, Akiko Okano, Shunji Takahashi, Masakazu Uramoto, Hideaki Konno, Tamio Saito, Hiroyuki Osada
Abstract
Systematic isolation of microbial metabolites has been performed to construct microbial metabolite libraries or fraction libraries. A novel macrolactam, verticilactam (1), was isolated from a library of Streptomyces spiroverticillatus JC-8444. The structure was determined on the basis of NMR and mass spectrometric measurements. 1 had a unique 16-membered macrolactam skeleton including a β-keto-amide moiety.
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