Hyrtioseragamines A and B, New Alkaloids from the Sponge Hyrtios Species
Organic Letters2011Vol. 13(4), pp. 628–631
Citations Over TimeTop 10% of 2011 papers
Yohei Takahashi, Yoshiro Iinuma, Takaaki Kubota, Masashi Tsuda, Mitsuhiro Sekiguchi, Yuzuru Mikami, Jane Fromont, Jun’ichi Kobayashi
Abstract
Two novel alkaloids with a furo[2,3-b]pyrazin-2(1H)-one moiety and a guanidino group, hyrtioseragamines A (1) and B (2), have been isolated from an Okinawan marine sponge Hyrtios species. The structures of 1 and 2 were elucidated on the basis of spectroscopic data and chemical conversions. Compounds 1 and 2 are the first natural products possessing a furo[2,3-b]pyrazine-related moiety.
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