Mild Addition of Nucleophiles to Pyridine-N-Oxides
Organic Letters2011Vol. 13(7), pp. 1840–1843
Citations Over TimeTop 10% of 2011 papers
Abstract
A general and facile one-pot procedure for the synthesis of 2-substituted pyridines from the corresponding pyridine-N-oxides and nucleophiles is presented as a mild alternative to S(N)Ar chemistry. A variety of nucleophiles and heterocyclic-N-oxides participate effectively in this transformation, which uses the phosphonium salt, PyBroP, as a means of substrate activation.
Related Papers
- → Propargylic Phosphonium Salts in Cobalt-Catalysed Diels-Alder Reactions(2006)16 cited
- → Phosphonium Salt Catalyzed Addition of Diethylzinc to Aldehydes(2011)15 cited
- → New alkyliodonium derivatives stabilized by ammonium or phosphonium groups(1999)11 cited
- → Studies on Ptc-Wittig Reaction of Diphenyl Ylids(1990)1 cited
- → ChemInform Abstract: Studies on PTC‐Wittig Reaction of Diphenyl Ylids.(1991)