Iron-Catalyzed Direct Alkenylation of 2-Substituted Azaarenes with N-Sulfonyl Aldimines via C–H Bond Activation
Organic Letters2011Vol. 13(10), pp. 2580–2583
Citations Over TimeTop 10% of 2011 papers
Abstract
A novel iron-catalyzed alkenylation of 2-substituted azaarenes through sp(3) C-H bond activation has been developed. A favorable E2-elimination is proposed as a key step to cleavage of C-H and C-N bonds for the construction of a C═C bond in high stereoselectivity. This transformation represents an efficient way to synthesize 2-alkenylated azaarenes from simple starting materials.
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