Simplextones A and B, Unusual Polyketides from the Marine Sponge Plakortis simplex
Organic Letters2011Vol. 13(12), pp. 3154–3157
Citations Over TimeTop 10% of 2011 papers
Xiang‐Fang Liu, Yunlong Song, Hongjun Zhang, Fan Yang, Hao‐Bing Yu, Wei‐Hua Jiao, Shu‐Juan Piao, Wansheng Chen, Hou‐Wen Lin
Abstract
Two novel polyketides, simplextones A (1) and B (2), were isolated from the sponge Plakortis simplex. Their structures were established by spectroscopic methods. The absolute configurations were assigned by modified Mosher's method, X-ray crystallographic analysis, and quantum mechanical calculation of the electronic circular dichroism (ECD) spectrum. Compounds 1 and 2 featured an unprecedented polyketide skeleton via the connection of a single carbon-carbon bond to form a cyclopentane. These compounds also exhibited moderate cytotoxicity.
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