Palladium-Catalyzed Oxidative C–H Bond Coupling of Steered Acetanilides and Aldehydes: A Facile Access to ortho-Acylacetanilides
Organic Letters2011Vol. 13(12), pp. 3258–3261
Citations Over TimeTop 1% of 2011 papers
Abstract
A palladium-catalyzed oxidative C-H bond functionalization/ortho-acylation of acetanilides using easily accessible aldehyde as the acyl source is described. In the presence of a Pd(TFA)(2) catalyst and tert-butylhydroperoxide at 90 °C in general, an array of ortho-acylacetanilides can be afforded in good yields.
Related Papers
- → THE ESTIMATION OF ACETANILIDE AND ITS METABOLIC PRODUCTS, ANILINE, N-ACETYL p-AMINOPHENOL AND p-AMINOPHENOL (FREE AND TOTAL CONJUGATED) IN BIOLOGICAL FLUIDS AND TISSUES(1948)324 cited
- → Oxidation of acetanilides to glycolanilides and oxanilic acids in rabbits(1969)36 cited
- → Metabolism of 2‐chloro‐N‐isopropylacetanilide (Propachlor) in the rat(1979)31 cited
- → Acetanilide mediated reversible assembly and disassembly of Au nanoparticles(2008)3 cited
- → Studies on Analysis of Pharmaceuticals. (II) : Gas Chromatography of Phenacetin and Acetanilide in Pharmaceutical Preparation.(1964)