Flueggines A and B, Two New Dimeric Indolizidine Alkaloids fromFlueggea virosa
Organic Letters2011Vol. 13(15), pp. 3888–3891
Citations Over TimeTop 10% of 2011 papers
Bing‐Xin Zhao, Ying Wang, Dongmei Zhang, Ren‐Wang Jiang, Guo‐Cai Wang, Jun-Min Shi, Xiao‐Jun Huang, Wei‐Min Chen, Chun‐Tao Che, Wen‐Cai Ye
Abstract
Two unprecedented C,C-linked dimeric indolizidine alkaloids, flueggines A (1) and B (2), were isolated from the twigs and leaves of Flueggea virosa. The structures and absolute configurations were elucidated by means of NMR, single-crystal X-ray diffraction, and CD analyses. Compound 1 is the first example of Securinega alkaloids bearing an isoxazolidine ring, the plausible biogenetic pathway of which is also proposed. Compound 2 exhibited growth inhibitory activity against MCF-7 and MDA-MB-231 human breast cancer cells.
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