Palladium-/Copper-Catalyzed Regioselective Amination and Chloroamination of Indoles
Organic Letters2011Vol. 13(16), pp. 4196–4199
Citations Over TimeTop 10% of 2011 papers
Abstract
A palladium-/copper-catalyzed intermolecular C-H amination reaction of indoles has been developed. This reaction proceeds in good to excellent yields to produce a variety of 2-amino-substituted indoles and exhibits excellent regioselectivity at room temperature. Furthermore, chloroamination of indoles provides a simple method for the construction of C-N and C-Cl bonds in one step.
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