Structures of the Dimeric and Monomeric Chromanones, Gonytolides A–C, Isolated from the Fungus Gonytrichum sp. and Their Promoting Activities of Innate Immune Responses
Organic Letters2011Vol. 13(17), pp. 4624–4627
Citations Over TimeTop 19% of 2011 papers
Haruhisa Kikuchi, Masato Isobe, Mizuki Sekiya, Yuko Abe, Tsuyoshi Hoshikawa, Kazunori Ueda, Shoichiro Kurata, Yasuhiro Katou, Yoshiteru Oshima
Abstract
Innate immunity is the front line of self-defense against microbial infection. After searching for natural substances that regulate innate immunity using an ex vivo Drosophila culture system, we identified a novel dimeric chromanone, gonytolide A, as an innate immune promoter from the fungus Gonytrichum sp. along with gonytolides B and C. Gonytolide A also increased TNF-α-stimulated production of IL-8 in human umbilical vein endothelial cells.
Related Papers
- → Innate recognition of intracellular pathogens: detection and activation of the first line of defense(2009)94 cited
- → Innate Immunological Defenses Against Bacterial Attack(2019)2 cited
- The damage on human umbilical vein endothelial cell lines induced by trichlorfon(2008)
- The Molecular Mechanism of the Proliferation of Human Umbilical Vein Endothelial Cells Induced by Angiolensin II(2005)
- TLR and control of innate immunity(2001)