A New Method for Aromatic Difluoromethylation: Copper-Catalyzed Cross-Coupling and Decarboxylation Sequence from Aryl Iodides
Organic Letters2011Vol. 13(20), pp. 5560–5563
Citations Over TimeTop 1% of 2011 papers
Abstract
A new methodology for aromatic difluoromethylation is described. Aryl iodides reacted with α-silyldifluoroacetates upon treatment with copper catalyst in DMSO or DME to give the corresponding aryldifluoroacetates in moderate to good yields. The subsequent hydrolysis of aryldifluoroacetates and KF-promoted decarboxylation afforded a variety of difluoromethyl aromatics.
Related Papers
- → A NOVEL DECARBOXYLATION OF α-AMINO ACIDS. A FACILE METHOD OF DECARBOXYLATION BY THE USE OF 2-CYCLOHEXEN-1-ONE AS A CATALYST(1986)65 cited
- → Studies in decarboxylation. Part 15. The effect of 3-substitution on the rate of decarboxylation of βγ-unsaturated acids(1982)6 cited
- → ChemInform Abstract: A Novel Decarboxylation of α‐Amino Acids. A Facile Method of Decarboxylation by the Use of 2‐Cyclohexen‐1‐one as a Catalyst.(1986)2 cited
- → Barton Decarboxylation(2010)1 cited
- → A novel method for monitoring of Δ 9 -tetrahydrocannabinolic acid and cannabidiolic acid thermal decarboxylation reactions in cannabis plant(2023)