Catalytic Asymmetric Construction of Spirocyclopentaneoxindoles by a Combined Ru-Catalyzed Cross-Metathesis/Double Michael Addition Sequence
Organic Letters2011Vol. 13(23), pp. 6200–6203
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Yingmei Li, Xiang Li, Fangzhi Peng, Ze‐Qian Li, Shou‐Tao Wu, Zhongwen Sun, Hongbin Zhang, Zhihui Shao
Abstract
Biologically important and synthetically challenging spirocyclopentaneoxindoles with four contiguous stereocenters including one spiroquaternary stereocenter have been constructed in good yields (72-87%) with excellent diastereoselectivity (16:1→30:1 dr) and enantioselectivity (93→99% ee) by a combined Ru-catalyzed cross-metathesis/organocatalyzed asymmetric double-Michael addition sequence.
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