Palladium-Catalyzed Synthesis of 4-Aminophthalazin-1(2H)-ones by Isocyanide Insertion
Organic Letters2011Vol. 13(24), pp. 6496–6499
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Tjøstil Vlaar, Eelco Ruijter, Anass Znabet, Elwin Janssen, Frans J. J. de Kanter, Bert U. W. Maes, Romano V. A. Orrù
Abstract
Palladium-catalyzed cross-coupling of a wide range of substituted o-(pseudo)halobenzoates and hydrazines with isocyanide insertion followed by lactamization efficiently affords 4-aminophthalazin-1(2H)-ones that are difficult to obtain regioselectively by classical methods.
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