Highly Regioselective Isomerization–Hydroaminomethylation of Internal Olefins Catalyzed by Rh Complex with Tetrabi-Type Phosphorus Ligands
Organic Letters2011Vol. 14(1), pp. 102–105
Citations Over TimeTop 11% of 2011 papers
Guodu Liu, Kexuan Huang, Bonan Cao, Mingxin Chang, Shengkun Li, Shichao Yu, Le Zhou, Wenjun Wu, Xumu Zhang
Abstract
A highly regioselective isomerization-hydroaminomethylation of internal olefins has been developed. A 95.3% amine selectivity and 36.2 n/i ratio were obtained for 2-octene with a Tetrabi ligand and Rh(acac)(CO)(2), and a TON of linear amine was achieved of 6837 with a 39.1 n/i ratio of amine. The m-CF(3)-Ph substituted ligand was the best of the applied Tetrabi-type phosphorus ligands for different internal olefins, as up to a 99.2% amine selectivity and 95.6 n/i ratio were obtained for 2-pentene.
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