The Decarboxylative Strecker Reaction
Organic Letters2011Vol. 13(24), pp. 6584–6587
Citations Over TimeTop 10% of 2011 papers
Abstract
α-Amino acids react with aldehydes in the presence of a cyanide source to form α-amino nitriles in what can be considered a decarboxylative variant of the classical Strecker reaction. This unprecedented transformation does not require the use of a metal catalyst and provides facile access to valuable α-amino nitriles that are inaccessible by traditional Strecker chemistry.
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