Toward the Synthesis of (+)-Peloruside A via an Intramolecular Vinylogous Aldol Reaction
Organic Letters2011Vol. 14(1), pp. 178–181
Citations Over TimeTop 10% of 2011 papers
Abstract
The use of the intramolecular vinylogous aldol reaction for the preparation of an advanced intermediate for the synthesis of peloruside A is described. The reaction was applied to compound 19 and proceeds in high yield and good levels of diastereoselectivity. Application of the Achmatowicz reaction to this intermediate provided the corresponding pyranone, a late stage intermediate well positioned for conversion to the natural product.
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