AlMe3-Promoted Formation of Amides from Acids and Amines
Organic Letters2011Vol. 14(1), pp. 214–217
Citations Over TimeTop 10% of 2011 papers
Jianqing Li, Subramaniam Krishnananthan, Daniel Smith, Jennifer X. Qiao, Jie Jack Li, Jingfang Qian‐Cutrone, John F. Kadow, Gregory D. Vite, Bang‐Chi Chen
Abstract
In the presence of AlMe(3), amines can be directly coupled with acids through dimethylaluminum amide intermediates to form the corresponding amides. A wide range of amines and acids including less nucleophilic amines, bulky amines, unprotected secondary amino acids, and acids with poor solubility were coupled smoothly to give the desired products in 55-98% yields.
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