Biomimetic Total Synthesis of (−)-Isatisine A
Organic Letters2012Vol. 14(6), pp. 1624–1627
Citations Over TimeTop 15% of 2012 papers
Abstract
The biomimetic total synthesis of (-)-isatisine A, a novel alkaloid with an unprecedented fused tetracyclic skeleton, was accomplished in 8 steps from indole and 4,6-O-isopropylidene-protected glucal. The synthesis features a convergent synthetic strategy which relies on nucleophilic addition and a biomimetic benzilic ester rearrangement as key reactions.
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