A Continuous Homologation of Esters: An Efficient Telescoped Reduction–Olefination Sequence
Organic Letters2012Vol. 14(10), pp. 2465–2467
Citations Over TimeTop 10% of 2012 papers
Abstract
A continuous protocol for the two-carbon homologation of esters to α,β-unsaturated esters is described. This multireactor homologation telescopes an ester reduction, phosphonate deprotonation, and Horner-Wadsworth-Emmons olefination, thus converting a three-operation procedure into a single, uninterrupted system that eliminates the need for isolation or purification of the aldehyde intermediates. The homologated products are obtained in high yield and selectivity.
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