HPLC-Assisted Automated Oligosaccharide Synthesis
Organic Letters2012Vol. 14(12), pp. 3036–3039
Citations Over TimeTop 10% of 2012 papers
Abstract
A standard HPLC was adapted to polymer supported oligosaccharide synthesis. Solution-based reagents are delivered using a software-controlled solvent delivery system. The reaction progress and completion can be monitored in real time using a standard UV detector. All steps of oligosaccharide assembly including loading, glycosylation, deprotection, and cleavage can be performed using this setup.
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